Extracellular DNA Impedes the Transport of Vancomycin in Staphylococcus epidermidis Biofilms Preexposed to Subinhibitory Concentrations of Vancomycin
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چکیده
منابع مشابه
Inhibition of Staphylococcus epidermidis Biofilms Using Polymerizable Vancomycin Derivatives
BACKGROUND Biofilm formation on indwelling medical devices is a ubiquitous problem causing considerable patient morbidity and mortality. In orthopaedic surgery, this problem is exacerbated by the large number and variety of material types that are implanted. Metallic hardware in conjunction with polymethylmethacrylate (PMMA) bone cement is commonly used. QUESTIONS/PURPOSES We asked whether po...
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Low concentrations of antibiotics can inhibit microbial adherence to medical device surfaces. However, little is known about the changes that occur in the physiology of bacteria within biofilms formed in the presence of subinhibitory (sub-MIC) concentrations of antibiotics. In this study, the densities and matrix compositions of biofilms formed by two coagulase-negative Staphylococcus species i...
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409. Efficacy of Vancomycin against Biofilms of Neonatal Staphylococcus epidermidis Bloodstream Isolates Maria Simitsopoulou, PhD; Daniela Kyrpitzi; Virginia Ramos Martin; William Hope; Emmanuel Roilides, MD, PhD; Pediatrics, Aristotle University of Thessaloniki, Thessaloniki, Greece; Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom; 3rd Pediatric Departme...
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OBJECTIVES Device-associated biofilm infections primarily caused by Staphylococcus epidermidis are difficult to treat effectively with conventional antibiotics. The aim of this study was to investigate the anti-biofilm effect of ultrasound-mediated microbubbles combined with vancomycin and to explore underlying mechanisms. METHODS Twenty-four hour S. epidermidis biofilms were established in O...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2014
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.03132-14